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Hypothermia for Perinatal Asphyxia: Clinical Effectiveness and Guidelines Hypothermia for Perinatal Asphyxia: Clinical Effectiveness and Guidelines | CADTH.ca Find the information you need Hypothermia for Perinatal Asphyxia: Clinical Effectiveness and Guidelines Hypothermia for Perinatal Asphyxia: Clinical Effectiveness and Guidelines Last updated: May 3, 2018 Project Number: RB1216-000 Product Line: Research Type: Devices and Systems Report Type: Summary of Abstracts Result type: Report (...) Question What is the clinical effectiveness on the various applications of hypothermia for neonates/newborns with perinatal asphyxia? What are the evidence-based guidelines regarding the use of hypothermia for neonates/newborns with perinatal asphyxia? Key Message Six randomized controlled trials, five non-randomized studies, and one evidence-based guideline were identified regarding the clinical effectiveness of hypothermia for neonates/newborns with perinatal asphyxia. Files Rapid Response Summary
HypothermiaHypothermia - Symptoms, diagnosis and treatment | BMJ Best Practice You'll need a subscription to access all of BMJ Best Practice Search Hypothermia Last reviewed: February 2019 Last updated: April 2018 Summary Characterised by the core body temperature lowering to <35°C (<95°F). As the core temperature approaches 32°C to 33°C (89.6°F-91.4°F), acute ST elevation and the J or Osborn wave may appear on the ECG tracing. These ECG changes are pathognomonic, but they are not always (...) present. Special low-reading rectal thermometers or rectal thermistor probes are preferred for measuring core body temperature. Initial management includes removing the patient from the cold environment, removing wet or cold clothing, warming the body with blankets, securing the airway, monitoring breathing, and maintaining circulation using warm intravenous fluids. Definition Hypothermia is a clinical condition characterised by the unintentional lowering of core body temperature below physiological
Effect of Therapeutic Hypothermia Initiated After 6 Hours of Age on Death or Disability Among Newborns With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. Hypothermia initiated at less than 6 hours after birth reduces death or disability for infants with hypoxic-ischemic encephalopathy at 36 weeks' or later gestation. To our knowledge, hypothermia trials have not been performed in infants presenting after 6 hours.To estimate the probability that hypothermia initiated at 6 to 24 (...) probability of reduced death or disability with hypothermia relative to the noncooled group (adjusted posterior risk ratio, 0.86; 95% credible interval, 0.58-1.29). The probability that death or disability in cooled infants was at least 1%, 2%, or 3% less than noncooled infants was 71%, 64%, and 56%, respectively.Among term infants with hypoxic-ischemic encephalopathy, hypothermia initiated at 6 to 24 hours after birth compared with noncooling resulted in a 76% probability of any reduction in death
Thermogenesis induced by amino acid administration prevents intraoperative hypothermia and reduces postoperative infectious complications after thoracoscopic esophagectomy. Minimally invasive thoracoscopic esophagectomy has potential advantages in minimizing the impairment of respiratory function and reducing surgical stress. However, thoracoscopic esophagectomy occasionally results in anesthesia-induced hypothermia, particularly in cases involving artificial pneumothorax with CO2 (...) . Thermogenesis induced by amino acid administration has been reported during anesthesia. Here, we tested the efficacy of amino acid treatment for the prevention of hypothermia, and we investigated the potential of this treatment to reduce postoperative infectious complications after thoracoscopic esophagectomy. We conducted a randomized trial in patients with esophageal cancer who underwent thoracoscopic esophagectomy in the prone position in two groups and analyzed the incidences of hypothermia and surgical
Case Report: Hypothermia and Traumatic Arrest in the Game of Thrones Game of Thrones Case Report - Hypothermia in Traumatic Cardiac Arrest Resuscitation Case Report: Hypothermia and Traumatic Arrest in the Game of Thrones In by Will Wu August 22, 2017 Be warned: this case report contains spoilers for Game of Thrones Season 5 and 6. Patient Presentation and History A 21-year-old man, by the name of Lord Commander Jon Snow, was discovered unconscious and unresponsive after receiving multiple stab (...) neurological outcome. In general, survival outcomes after TCA are poor with rates of approximately 7.5%. 1 Location may have played an important role in his recovery as Castle Black is in the North, where “They say it grows so cold…that a man’s laughter freezes in his throat and chokes him to death.” Hypothermia, which is generally classified in ranges of mild (32-35°C), moderate (30-32°C), or severe (<30°C) 2 , could have complicated this case in several ways: The presumption of death. Patients with core
Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. Targeted temperature management is recommended for comatose adults and children after out-of-hospital cardiac arrest; however, data on temperature management after in-hospital cardiac arrest are limited.In a trial conducted at 37 children's hospitals, we compared two temperature interventions in children who had had in-hospital cardiac arrest. Within 6 hours after the return of circulation, comatose children older than 48 (...) hours and younger than 18 years of age were randomly assigned to therapeutic hypothermia (target temperature, 33.0°C) or therapeutic normothermia (target temperature, 36.8°C). The primary efficacy outcome, survival at 12 months after cardiac arrest with a score of 70 or higher on the Vineland Adaptive Behavior Scales, second edition (VABS-II, on which scores range from 20 to 160, with higher scores indicating better function), was evaluated among patients who had had a VABS-II score of at least 70
Hypothermia for Neuroprotection in Convulsive Status Epilepticus. Convulsive status epilepticus often results in permanent neurologic impairment. We evaluated the effect of induced hypothermia on neurologic outcomes in patients with convulsive status epilepticus.In a multicenter trial, we randomly assigned 270 critically ill patients with convulsive status epilepticus who were receiving mechanical ventilation to hypothermia (32 to 34°C for 24 hours) in addition to standard care or to standard (...) anesthesia), and functional sequelae on day 90.A GOS score of 5 occurred in 67 of 138 patients (49%) in the hypothermia group and in 56 of 130 (43%) in the control group (adjusted common odds ratio, 1.22; 95% confidence interval [CI], 0.75 to 1.99; P=0.43). The rate of progression to EEG-confirmed status epilepticus on the first day was lower in the hypothermia group than in the control group (11% vs. 22%; odds ratio, 0.40; 95% CI, 0.20 to 0.79; P=0.009), but there were no significant differences between
Effect of Prehospital Induction of Mild Hypothermia on Survival and Neurological Status Among Adults With Cardiac Arrest: A Randomized Clinical Trial PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Moderate hypothermia and its effects in reducing the applied dose of anesthetics for patients with opium dependence in cardiac surgery: A randomized controlled trial. An increasing number of patients addicted to opium are experiencing awareness during coronary artery bypass surgery (CABG) as a result of tolerance to anesthetics.This research was primarily intended to determine the potential diminishing effects of moderate hypothermia on anesthetic dosage and recall of anesthesia during (...) ±13.11 cc for normothermic patients and 101.28±14.06 cc for hypothermic subjects (p=0.001). As for fentanyl, the total required sum came up to 39.60±21.04 cc and 31.72±5.81 cc for the above-mentioned groups in order (p=0.025). Moreover, the post-operative interview showed that there was no report of a patient with memory recall following surgery.Moderate hypothermia can substantially reduce the need for anesthetics in patients with addiction to opium when undergoing CABG surgery.This study
Association Between Therapeutic Hypothermia and Survival After In-Hospital Cardiac Arrest. Therapeutic hypothermia is used for patients following both out-of-hospital and in-hospital cardiac arrest. However, randomized trials on its efficacy for the in-hospital setting do not exist, and comparative effectiveness data are limited.To evaluate the association between therapeutic hypothermia and survival after in-hospital cardiac arrest.In this cohort study, within the national Get (...) With the Guidelines-Resuscitation registry, 26 183 patients successfully resuscitated from an in-hospital cardiac arrest between March 1, 2002, and December 31, 2014, and either treated or not treated with hypothermia at 355 US hospitals were identified. Follow-up ended February 4, 2015.Induction of therapeutic hypothermia.The primary outcome was survival to hospital discharge. The secondary outcome was favorable neurological survival, defined as a Cerebral Performance Category score of 1 or 2 (ie, without severe
Early Bispectral Index and Sedation Requirements During Therapeutic Hypothermia Predict Neurologic Recovery Following Cardiac Arrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?
Hyperoxia is associated with increased mortality in patients treated with mild therapeutic hypothermia after sudden cardiac arrest PEDSCCM.org Criteria abstracted from series in Review Posted: founded 1995 Questions or comments?