Chronic Pain in Veterans and Service members with a History of Mild Traumatic Brain Injury: A Systematic Review ? August 2020 Prepared for: Department of Veterans Affairs Veterans Health Administration Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence Synthesis Program (ESP) Center Portland VA Medical Center Portland, OR Devan Kansagara, MD, MCR, Director Chronic Pain in Veterans and Servicemembers with a History of Mild Traumatic Brain Injury (...) for review topics several times a year via the program website. Comments on this evidence report are welcome and can be sent to Nicole Floyd, Deputy Director, ESP Coordinating Center at Nicole.Floyd@va.gov. Recommended citation: O’Neil ME, Carlson KF, Holmer HK, Ayers CK, Morasco BJ, Kansagara D, Kondo K. Chronic Pain in Veterans and Servicemembers with a History of Mild Traumatic Brain Injury: A Systematic Review. Washington, DC: Evidence Synthesis Program, Health Services Research and Development

Comparison of Diagnostic Sleep Studies in Hospitalized Neurorehabilitation Patients With Moderate to Severe Traumatic Brain Injury Comparison of Diagnostic Sleep Studies in Hospitalized Neurorehabilitation Patients With Moderate to Severe Traumatic Brain Injury - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. COVID-19 is an emerging (...) 2020 May 6. Comparison of Diagnostic Sleep Studies in Hospitalized Neurorehabilitation Patients With Moderate to Severe Traumatic Brain Injury , , , , , , , , , , , Affiliations Expand Affiliations 1 Mental Health and Behavioral Sciences, Defense and Veterans Brain Injury Center, James A. Haley Veterans' Hospital, Morsani College of Medicine, Division of Pulmonary and Sleep Medicine, University of South Florida, Tampa, FL. Electronic address: Risa.Richardson@va.gov. 2 Medicine Service, James

Chronic Pain in Veterans and Servicemembers with a History of Mild Traumatic Brain Injury: A Systematic Review Management Briefs eBrief-no177 -- Biological Measures and Diagnostic Tools for Gulf War Illness: A Systematic Review Talk to the Veterans Crisis Line now An official website of the United States government Here's how you know The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal (...) eBrief-no177 -- Biological Measures and Diagnostic Tools for Gulf War Illness: A Systematic Review Health Services Research & Development Management eBrief No. 177 » Issue 177 October 2020 The report is a product of the VA/HSR&D Evidence Synthesis Program. Chronic Pain in Veterans and Servicemembers with a History of Mild Traumatic Brain Injury: A Systematic Review Mild traumatic brain injury (mTBI) often resolves completely and quickly, without the need for much or any intervention. However, up

Effect of Out-of-Hospital Tranexamic Acid vs Placebo on 6-Month Functional Neurologic Outcomes in Patients With Moderate or Severe Traumatic Brain Injury. Traumatic brain injury (TBI) is the leading cause of death and disability due to trauma. Early administration of tranexamic acid may benefit patients with TBI.To determine whether tranexamic acid treatment initiated in the out-of-hospital setting within 2 hours of injury improves neurologic outcome in patients with moderate or severe (...) -day mortality between the tranexamic acid groups vs the placebo group (14% vs 17%; difference, -2.9% [95% CI, -7.9% to 2.1%]; P = .26), 6-month Disability Rating Scale score (6.8 vs 7.6; difference, -0.9 [95% CI, -2.5 to 0.7]; P = .29), or progression of intracranial hemorrhage (16% vs 20%; difference, -5.4% [95% CI, -12.8% to 2.1%]; P = .16).Among patients with moderate to severe TBI, out-of-hospital tranexamic acid administration within 2 hours of injury compared with placebo did

Physical Therapy Evaluation and Treatment After Concussion/Mild Traumatic Brain Injury Clinical Practice Guidelines CATHERINE C. QUATMAN-YATES, PT , DPT , PhD • AIRELLE HUNTER-GIORDANO, PT , DPT KATHY K. SHIMAMURA, PT , DPT , NCS, OCS, CSCS, FAAOMPT • ROB LANDEL, PT , DPT , FAPTA BARA A. ALSALAHEEN, PT , PhD • TIMOTHY A. HANKE, PT , PhD • KAREN L. McCULLOCH, PT , PhD, FAPTA Physical Therapy Evaluation and Treatment After Concussion/ Mild Traumatic Brain Injury Clinical Practice Guidelines (...) : International Classification of Functioning, Disability and Health mTBI: mild traumatic brain injury PECARN: Pediatric Emergency Care Applied Research Network RCT: randomized controlled trial VOMS: Vestibular/Ocular Motor Screening Journal of Orthopaedic & Sports Physical Therapy® Downloaded from www.jospt.org at on April 14, 2020. For personal use only. No other uses without permission. Copyright © 2020 Journal of Orthopaedic & Sports Physical Therapy®. All rights reserved.cpg6 | april 2020 | volume 50

Association of clinically important traumatic brain injury and Glasgow Coma Scale scores in children with head injury Association of Clinically Important Traumatic Brain Injury and Glasgow Coma Scale Scores in Children With Head Injury - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily (...) Create file Cancel Actions Cite Share Permalink Copy Page navigation Emerg Med J Actions . 2020 Mar;37(3):127-134. doi: 10.1136/emermed-2018-208154. Epub 2020 Feb 12. Association of Clinically Important Traumatic Brain Injury and Glasgow Coma Scale Scores in Children With Head Injury , , , , , , , , , , , , Affiliations Expand Affiliations 1 Emergency Department, Women's and Children's Hospital, Adelaide, SA, Australia amit.kochar@sa.gov.au. 2 PREDICT, Paediatric Research in Emergency Departments

Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial - PubMed This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Welcome to the new PubMed. For legacy PubMed go to . Clipboard, Search History, and several other advanced features are temporarily unavailable. National Institutes of Health U.S (...) Permalink Copy Page navigation World J Surg Actions . 2020 Jan 30. doi: 10.1007/s00268-020-05391-8. Online ahead of print. Beta-Blocker Therapy in Severe Traumatic Brain Injury: A Prospective Randomized Controlled Trial , , , , , , , , , Affiliations Expand Affiliations 1 Department of Neurosurgery, Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Department of Surgery, Karolinska University Hospital, Stockholm, Sweden. 3 School

Tranexamic acid is safe to use following mild-to-moderate traumatic brain injury. The studyThe CRASH-3 Trial Collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial.Lancet 2019;394:1713-23.This trial was funded by NIHR Health Technology Assessment Programme (project number 14/190/01), JP Moulton Charitable Trust, Department of Health and Social (...) Care, Department for International Development, Global Challenges Research Fund, Medical Research Council, and the Wellcome Trust (Joint Global Health Trials scheme).To read the full NIHR Signal, go to: https://discover.dc.nihr.ac.uk/content/signal-000870/tranexamic-acid-following-mild-to-moderate-traumatic-brain-injury-is-safe-and-reduces-deaths.Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group

Hypertonic saline versus other intracranial pressure-lowering agents for people with acute traumatic brain injury. Increased intracranial pressure has been shown to be strongly associated with poor neurological outcomes and mortality for patients with acute traumatic brain injury. Currently, most efforts to treat these injuries focus on controlling the intracranial pressure. Hypertonic saline is a hyperosmolar therapy that is used in traumatic brain injury to reduce intracranial pressure (...) . The effectiveness of hypertonic saline compared with other intracranial pressure-lowering agents in the management of acute traumatic brain injury is still debated, both in the short and the long term.To assess the comparative efficacy and safety of hypertonic saline versus other intracranial pressure-lowering agents in the management of acute traumatic brain injury.We searched Cochrane Injuries' Specialised Register, CENTRAL, PubMed, Embase Classic+Embase, ISI Web of Science: Science Citation Index

Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury. High intracranial pressure (ICP) is the most frequent cause of death and disability after severe traumatic brain injury (TBI). It is usually treated with general maneuvers (normothermia, sedation, etc.) and a set of first-line therapeutic measures (moderate hypocapnia, mannitol, etc.). When these measures fail, second-line therapies are initiated, which include: barbiturates (...) care (this could include induced barbiturate coma or cooling of the brain, or both). All trials measured outcomes up to six months after injury; one also measured outcomes at 12 and 24 months (the latter data remain unpublished). All trials were at a high risk of bias for the criterion of performance bias, as neither participants nor personnel could be blinded to these interventions. The pediatric trial was at a high risk of selection bias and stopped early; another trial was at risk of bias

Hypertonic saline versus other intracranial pressure-lowering agents for people with acute traumatic brain injury. Increased intracranial pressure (ICP) has been shown to be strongly associated with poor neurological outcomes and mortality for patients with acute traumatic brain injury (TBI). Currently, most efforts to treat these injuries focus on controlling the ICP. Hypertonic saline (HTS) is a hyperosmolar therapy that is used in traumatic brain injury to reduce intracranial pressure (...) . The effectiveness of HTS compared with other ICP-lowering agents in the management of acute TBI is still debated, both in the short and the long term.To assess the comparative efficacy and safety of hypertonic saline versus other ICP-lowering agents in the management of acute TBI.We searched the Cochrane Injuries Group's Specialised Register, The Cochrane Library, PubMed, Embase Classic+Embase (OvidSP), ISI Web of Science: Science Citation Index and Conference Proceedings Citation Index-Science, as well

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. Tranexamic acid reduces surgical bleeding and decreases mortality in patients with traumatic extracranial bleeding. Intracranial bleeding is common after traumatic brain injury (TBI) and can cause brain herniation and death. We aimed to assess the effects of tranexamic acid in patients with TBI.This (...) randomised, placebo-controlled trial was done in 175 hospitals in 29 countries. Adults with TBI who were within 3 h of injury, had a Glasgow Coma Scale (GCS) score of 12 or lower or any intracranial bleeding on CT scan, and no major extracranial bleeding were eligible. The time window for eligibility was originally 8 h but in 2016 the protocol was changed to limit recruitment to patients within 3 h of injury. This change was made blind to the trial data, in response to external evidence suggesting

Feasibility and Accuracy of Fast MRI Versus CT for Traumatic Brain Injury in Young Children Computed tomography (CT) is commonly used for children when there is concern for traumatic brain injury (TBI) and is a significant source of ionizing radiation. Our objective was to determine the feasibility and accuracy of fast MRI (motion-tolerant MRI sequences performed without sedation) in young children.In this prospective cohort study, we attempted fast MRI in children <6 years old who had head CT (...) performed and were seen in the emergency department of a single, level 1 pediatric trauma center. Fast MRI sequences included 3T axial and sagittal T2 single-shot turbo spin echo, axial T1 turbo field echo, axial fluid-attenuated inversion recovery, axial gradient echo, and axial diffusion-weighted single-shot turbo spin echo planar imaging. Feasibility was assessed by completion rate and imaging time. Fast MRI accuracy was measured against CT findings of TBI, including skull fracture, intracranial

Can the important brain injury criteria predict neurosurgical intervention in mild traumatic brain injury? A validation study. There is variability in the management of patients presenting to the emergency department (ED) with mild traumatic brain injury (MTBI) and abnormal findings on their initial head computed tomography (CT). The main objective of this study was to validate the value of the Important Brain Injury (IBI) criteria, introduced by the Canadian CT-Head Rule, in predicting

Comparison of Effects of Manual and Mechanical Airway Clearance Techniques on Intracranial Pressure in Patients With Severe Traumatic Brain Injury on a Ventilator: Randomized, Crossover Trial Physical therapist intervention can play a significant role in the prevention of mechanical and infectious complications in patients with traumatic brain injury (TBI) who are mechanically ventilated.The objective of this study was to observe and compare the effects of manual and mechanical airway clearance (...) techniques on intracranial pressure (ICP) and hemodynamics in patients with severe TBI.The design was a prospective, randomized, crossover trial.The setting was a neurointensive care unit at a level 1 trauma center.Forty-six adult patients aged 18 to 75 years, of either sex, with severe TBI, receiving mechanical ventilatory support with continuous ICP monitoring, and undergoing regular airway clearance techniques participated in this study.Two techniques were performed by a single trained physical

Message S100B serum biomarker has high sensitivity and negative predictive value for detecting traumatic intracranial lesions in children with mild traumatic brain injury. However, how to incorporate this into existing risk-stratification tools is unclear, and reduced availability of the test currently limits its practical application in the emergency department (ED). Methods Data Sources The authors searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials, Web of Science, Scopus (...) . The 8 included studies comprised 601 children with mild traumatic brain injury who underwent serum S100B biomarker testing compared with head CT or clinical follow-up as the references standard. S100B levels for detecting traumatic intracranial lesions in children with mild traumatic brain injury had a pooled sensitivity of 100% (95% CI 98% to 100%) and negative predictive value of 100% (95% CI 99% to 100%), whereas the pooled specificity was 41% (95% CI 26% to 57%), with significant heterogeneity

Systematic Review - Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders 4 March 2019 Prepared for: Department of Veterans Affairs Veterans Health Administration Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence Synthesis Program (ESP) Center Portland VA Medical Center Portland, OR Mark Helfand, MD, MPH, MS, Director (...) Relationship of Deployment-related Mild Traumatic Brain Injury to Posttraumatic Stress Disorder, Depressive Disorders, Substance Use Disorders, Suicidal Ideation, and Anxiety Disorders: A Systematic Review Authors: Principal Investigator: Nancy Greer, PhD Timothy J. Wilt, MD, MPH Co-Investigators: Princess Ackland, PhD, MSPH Roderick MacDonald, MS Nina Sayer, PhD Michele Spoont, PhD Brent Taylor, PhD Research Assistants: Lauren McKenzie, MPH Christina Rosebush, MPH Evidence Synthesis Program 4 Relationship

Evidence Brief: Traumatic Brain Injury and Dementia Management Briefs eBrief-no150 -- Traumatic Brain Injury and Dementia Enter search terms Button to search HSRD ® Inside VA Budget and Performance Inside the News Room National Observances Special Events » » » » » Management Briefs eBrief-no150 -- Traumatic Brain Injury and Dementia Health Services Research & Development Management eBrief no. 150 » Issue 150 March 2019 The report is a product of the VA/HSR&D Evidence Synthesis Program. Evidence (...) Brief: Traumatic Brain Injury and Dementia Traumatic brain injury (TBI) is a common condition among both civilian and military populations. While some TBIs cause acute symptoms that resolve over several weeks or months, evidence accumulated over nearly three decades suggests that TBI may lead to chronic neurodegenerative diseases such as dementia. More public awareness about TBI in active-duty service members as a risk factor for earlier onset of dementia and/or of Chronic Traumatic Encephalopathy

Traumatic Brain Injury and Dementia 4 February 2019 Prepared for: Department of Veterans Affairs Veterans Health Administration Health Services Research & Development Service Washington, DC 20420 Prepared by: Evidence Synthesis Program (ESP) Coordinating Center Portland VA Health Care System Portland, OR Mark Helfand, MD, MPH, MS, Director Evidence Brief: Traumatic Brain Injury and Dementia Authors: Kim Peterson, MS Stephanie Veazie, MPH Donald Bourne, MPH Johanna Anderson, MPH Evidence (...) , Veazie S, Bourne D, Anderson J. Evidence Brief: Traumatic Brain Injury and Dementia. VA ESP Project #09-199; 2019. Posted final reports are located on the ESP search page. This report is based on research conducted by the Evidence Synthesis Program (ESP) Center located at the Portland VA Health Care System, Portland, OR, funded by the Department of Veterans Affairs, Veterans Health Administration, Health Services Research and Development. The findings and conclusions in this document are those

. 1996;6(2):97-101. Ryan AJ. Intracranial injuries resulting from boxing. Clin Sports Med. 1998;17(1):155-168. doi:10.1016/S0278-5919(05)70070-3. Blennow K, Hardy J, Zetterberg H. The neuropathology and neurobiology of traumatic brain injury. Neuron. 2012;76(5):886-899. doi:10.1016/j.neuron.2012.11.021. McCrory P, Feddermann-Demont N, Dvorak J, et al. What is the definition of sports-related concussion: a systematic review. Br J Sports Med. 2017;51(11):877–887. doi:10.1136/bjsports-2016-097393. Baugh (...) Is traumatic brain injury preventable in amateur boxing competition? Is Traumatic Brain Injury Preventable in Amateur Boxing Competition? – Clinical Correlations Search Is Traumatic Brain Injury Preventable in Amateur Boxing Competition? January 18, 2019 5 min read By Kevin Rezzadeh Peer Reviewed Injuries associated with amateur . 1 While many of the superficial wounds and bone fractures can completely heal, brain damage secondary to boxing has also been well 2 Boxers are at risk for sequelae